Abstract
Objective: To systematically analyze the risk factors of free flap failure. Method: To retrieve the literature pertaining to the study of risk factors for the failure of free flap transplantation published prior to November 10, 2022, the following databases were searched: Pubmed, Web Of Science, Embase, Medline, CNKI, Wanfang, and CBM. The included and excluded criteria were applied to screen the literature that met the standards. The Newcastle-Ottawa Scale (NOS) was utilized to assess the quality of the included studies, and the RevMan 5.4 software was employed to conduct the meta-analysis of the included literature. Result: Among the 14 included studies, encompassing a total of 32,325 subjects, the following 16 risk factors were identifi ed as contributors to the failure of free flap transplantation: body mass index (BMI) (OR = 1.81, 95% CI [1.10, 2.98]), smoking history (OR = 1.58, 95% CI [1.02, 2.45]), diabetes (OR = 1.92, 95% CI [1.04, 3.56]), hypertension (OR = 1.41, 95% CI [1.01, 1.97]), ASA score (OR = 0.62, 95% CI [0.46, 0.84]), surgical duration (OR = 0.47, 95% CI [0.09, 0.86]), intraoperative blood loss (OR = 0.21, 95% CI [0.08, 0.54]), and artery-to-vein ratio (OR = 3.71, 95% CI [2.00, 6.89]). These factors significantly influence the likelihood of transplant failure in free flap transplantation patients. Con clusion: The general condition, medical history, and treatment of patients undergoing free flap transplantation can all potentially impact the occurrence of surgical failure. It is crucial in clinical practice to accurately identify individuals at high risk for free flap transplantation and promptly intervene to address relevant risk factors, thus enhancing the overall surgical outcomes.
Keywords
Flap; Free flap transplantation; Risk factors; Meta-analysis
References
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