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Synthesis and Biological Evaluation of PEGylated Antimicrobial Peptide

Can Yu, Yu Chai, Xunxiang Qiu, Yang Wan

Abstract


Antimicrobial peptides (AMPs) possess strong antibacterial activity but are often associated with undesirable hemolytic activity, cytotoxicity, and sensitivity to proteolysis. Here, we report a simple and efficient prodrug system that combines antimicrobial peptides with photo-releasable PEG, successfully applied to the linear peptide indolicidin. After modification, this peptide significantly reduced hemolytic and cytotoxic effects while enhancing stability against proteolysis. Under irradiation conditions, the AMP is released, demonstrating antibacterial activity comparable to that of natural products.

Keywords


AMPs; Photo-releasable; PEGylation; Spatiotemporal release

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References


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DOI: http://dx.doi.org/10.18686/ahe.v8i8.13761

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