Progress in Alzheimer's Disease Research Based on SIRT1
Abstract
SIRT1 belongs to the family of Sirtuins deacetylase in mammals, which is mainly responsible for regulating the anti-infection, anti-apoptosis and anti-oxidative stress ability of cells. When organisms show degenerative changes in the nervous system, the expression level of SIRT1 will be up-regulated in order to play a protective role in the nervous system. In order to clarify the interaction between SIRT1 and Alzheimer's disease, this paper aims to provide scientific theoretical basis for the treatment of Alzheimer's disease by analyzing the regulation mechanism of SIRT1.
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Robert A Cherny, Craig S Atwood, Michel Xilinas. Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice [J]. Neuron 2001; 30(3): 665-676.
Sanan, D A, Weisgraber, K H, Russell, S J. Apolipoprotein E associates with beta amyloid peptide of Alzheimer"s disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3 [J]. Journal of Clinical Investigation 94(2): 860-869.
Doody, Rachelle S, Raman, Rema, Farlow, Martin. A Phase 3 Trial of Semagacestat for Treatment of Alzheimer"s Disease [J]. New England Journal of Medicine 369(4): 341-350.
Elliott PJ, JirousekM.Sirtuins: Novel targets for metabolic disease [J]. CurrOpinInvestig Drugs 2008; 9(4): 371-378.
DOI: http://dx.doi.org/10.18686/ahe.v3i2.1445
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